Tissue expression of MGEA5 - Summary - The Human Protein Atlas

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MGEA5

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MGEA5
Gene description	Meningioma expressed antigen 5 (hyaluronidase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036141
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MGEA5 (HGNC Symbol)
Synonyms	MEA5, NCOAT, OGA
Description	Meningioma expressed antigen 5 (hyaluronidase) (HGNC Symbol)
Entrez gene summary	The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	101784443 - 101818465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198408 (version 83.38)
Entrez gene	10724
UniProt	O60502 (UniProt - Evidence at protein level)
neXtProt	NX_O60502
Antibodypedia	MGEA5 antibodies

PROTEIN BROWSER

MGEA5-002	MGEA5-003	MGEA5-004	MGEA5-005	MGEA5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGEA5-002 ENSP00000414235 ENST00000429860	H7C3X0 [Direct mapping] Protein O-GlcNAcase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.7 kDa	No	0
MGEA5-003 ENSP00000354850 ENST00000361464	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	916 aa 102.9 kDa	No	0
MGEA5-004 ENSP00000350445 ENST00000357797	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	849 aa 95.3 kDa	No	0
MGEA5-005 ENSP00000359112 ENST00000370094	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	677 aa 76.2 kDa	No	0
MGEA5-201 ENSP00000409973 ENST00000439817	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	863 aa 96.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.