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TXNRD1

GENERAL INFORMATION

Gene name

 TXNRD1

Gene description

 Thioredoxin reductase 1

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA001395 , CAB004607 , CAB015834
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001395
CAB004607
CAB015834

GENE INFORMATION

Gene name

 TXNRD1 (HGNC Symbol)

Synonyms

 GRIM-12, Trxr1, TXNR

Description

 Thioredoxin reductase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 104215779 - 104350305

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198431 (version 83.38)

Entrez gene

 7296

UniProt

 Q16881 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16881

Antibodypedia

 TXNRD1 antibodies

PROTEIN BROWSER
«
TXNRD1-001
TXNRD1-002
TXNRD1-003
TXNRD1-004
TXNRD1-005
TXNRD1-006
TXNRD1-009
TXNRD1-012
TXNRD1-013
TXNRD1-014
TXNRD1-015
TXNRD1-016
TXNRD1-017
TXNRD1-020
TXNRD1-021
TXNRD1-201
TXNRD1-202
TXNRD1-203
TXNRD1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNRD1-001
ENSP00000434516
ENST00000525566
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001707 [mesoderm formation]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007369 [gastrulation]
GO:0008283 [cell proliferation]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 649 aa
70.9 kDa 		No 0
TXNRD1-002
ENSP00000435929
ENST00000526691
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 551 aa
60.4 kDa 		No 0
TXNRD1-003
ENSP00000421934
ENST00000503506
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 499 aa
54.8 kDa 		No 0
TXNRD1-004
ENSP00000434919
ENST00000529546
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50.9 kDa 		No 0
TXNRD1-005
ENSP00000433887
ENST00000526580
A0A0B4J225 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 104 aa
11.3 kDa 		No 0
TXNRD1-006
ENSP00000433425
ENST00000524698
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 499 aa
54.8 kDa 		No 0
TXNRD1-009
ENSP00000432812
ENST00000526950
E9PNQ6 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005623 [cell]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 568 aa
62.1 kDa 		No 0
TXNRD1-012
ENSP00000431294
ENST00000526266
E9PLT3 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 70 aa
7.3 kDa 		No 0
TXNRD1-013
ENSP00000433507
ENST00000531689
E9PKI4 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 72 aa
7.6 kDa 		No 0
TXNRD1-014
ENSP00000433599
ENST00000527335
E9PKD3 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 175 aa
19.4 kDa 		No 0
TXNRD1-015
ENSP00000436229
ENST00000529784
E9PQI3 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 53 aa
5.6 kDa 		No 0
TXNRD1-016
ENSP00000431925
ENST00000531691
E9PIZ5 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 139 aa
15.1 kDa 		No 0
TXNRD1-017
ENSP00000435123
ENST00000526390
Q16881 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 543 aa
59.8 kDa 		No 0
TXNRD1-020
ENSP00000433732
ENST00000528079
E9PJU2 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 96 aa
10.1 kDa 		No 0
TXNRD1-021
ENSP00000432273
ENST00000529751
E9PRI8 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 44 aa
4.8 kDa 		No 0
TXNRD1-201
ENSP00000347020
ENST00000354940
F8W809 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005623 [cell]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 498 aa
54.6 kDa 		No 0
TXNRD1-202
ENSP00000373506
ENST00000388854
A0A087WSW9 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005623 [cell]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 548 aa
60.1 kDa 		No 0
TXNRD1-203
ENSP00000380844
ENST00000397736
E2QRB9 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 460 aa
50.7 kDa 		No 0
TXNRD1-204
ENSP00000412045
ENST00000429002
A0A087WSY9 [Direct mapping]
Thioredoxin reductase 1, cytoplasmic
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004791 [thioredoxin-disulfide reductase activity]
GO:0005623 [cell]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016491 [oxidoreductase activity]
GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor]
GO:0045454 [cell redox homeostasis]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 648 aa
70.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.