Expression of YTHDF2 in cancer - Summary - The Human Protein Atlas

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YTHDF2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	YTHDF2
Gene description	YTH N(6)-methyladenosine RNA binding protein 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues with variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA059621
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059621

GENE INFORMATION
Gene name	YTHDF2 (HGNC Symbol)
Synonyms	CAHL, HGRG8, NY-REN-2
Description	YTH N(6)-methyladenosine RNA binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Chromosome	1
Cytoband	p35.3
Chromosome location (bp)	28736621 - 28769775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198492 (version 83.38)
Entrez gene	51441
UniProt	Q9Y5A9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5A9
Antibodypedia	YTHDF2 antibodies

PROTEIN BROWSER

YTHDF2-001	YTHDF2-003	YTHDF2-006	YTHDF2-008	YTHDF2-201	YTHDF2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
YTHDF2-001 ENSP00000362918 ENST00000373812	Q9Y5A9 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0006959 [humoral immune response] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:1990247 [N6-methyladenosine-containing RNA binding] Show all	579 aa 62.3 kDa	No	0
YTHDF2-003 ENSP00000474446 ENST00000474884	S4R3J8 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		200 aa 21 kDa	No	0
YTHDF2-006 ENSP00000474784 ENST00000496288	S4R3V3 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 24.9 kDa	No	0
YTHDF2-008 ENSP00000439394 ENST00000541996	Q9Y5A9 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0006959 [humoral immune response] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:1990247 [N6-methyladenosine-containing RNA binding] Show all	529 aa 56.9 kDa	No	0
YTHDF2-201 ENSP00000444660 ENST00000542507	Q9Y5A9 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0006959 [humoral immune response] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:1990247 [N6-methyladenosine-containing RNA binding] Show all	579 aa 62.3 kDa	No	0
YTHDF2-202 ENSP00000481408 ENST00000621244	A0A087WXZ3 [Direct mapping] YTH domain-containing family protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		569 aa 61.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.