Expression of DDX39B in cancer - Summary - The Human Protein Atlas

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DDX39B

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDX39B
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA055334 , HPA058450 , CAB034012
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055334	HPA058450	CAB034012

GENE INFORMATION
Gene name	DDX39B (HGNC Symbol)
Synonyms	BAT1, D6S81E, UAP56
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31530219 - 31542448
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198563 (version 83.38)
Entrez gene	7919
UniProt	Q13838 (UniProt - Evidence at protein level)
neXtProt	NX_Q13838
Antibodypedia	DDX39B antibodies

PROTEIN BROWSER

DDX39B-001	DDX39B-002	DDX39B-006	DDX39B-009	DDX39B-010	DDX39B-011	DDX39B-012	DDX39B-013	DDX39B-014	DDX39B-016	DDX39B-017	DDX39B-018	DDX39B-019	DDX39B-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX39B-001 ENSP00000379475 ENST00000396172	Q13838 [Direct mapping] Spliceosome RNA helicase DDX39B A0A024RCM3 [Target identity:100%; Query identity:100%] HCG2005638, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000245 [spliceosomal complex assembly] GO:0000346 [transcription export complex] GO:0000398 [mRNA splicing, via spliceosome] GO:0001889 [liver development] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005687 [U4 snRNP] GO:0005688 [U6 snRNP] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0006974 [cellular response to DNA damage stimulus] GO:0008186 [RNA-dependent ATPase activity] GO:0008380 [RNA splicing] GO:0010501 [RNA secondary structure unwinding] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0017070 [U6 snRNA binding] GO:0030621 [U4 snRNA binding] GO:0032403 [protein complex binding] GO:0032786 [positive regulation of DNA-templated transcription, elongation] GO:0043008 [ATP-dependent protein binding] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] GO:0045727 [positive regulation of translation] GO:0046784 [viral mRNA export from host cell nucleus] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:1904707 [positive regulation of vascular smooth muscle cell proliferation] GO:2000002 [negative regulation of DNA damage checkpoint] GO:2000573 [positive regulation of DNA biosynthetic process] Show all	428 aa 49 kDa	No	0
DDX39B-002 ENSP00000416269 ENST00000458640	Q13838 [Direct mapping] Spliceosome RNA helicase DDX39B A0A024RCM3 [Target identity:100%; Query identity:100%] HCG2005638, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000245 [spliceosomal complex assembly] GO:0000346 [transcription export complex] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005687 [U4 snRNP] GO:0005688 [U6 snRNP] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0006974 [cellular response to DNA damage stimulus] GO:0008186 [RNA-dependent ATPase activity] GO:0008380 [RNA splicing] GO:0010501 [RNA secondary structure unwinding] GO:0016607 [nuclear speck] GO:0017070 [U6 snRNA binding] GO:0030621 [U4 snRNA binding] GO:0032786 [positive regulation of DNA-templated transcription, elongation] GO:0043008 [ATP-dependent protein binding] GO:0044822 [poly(A) RNA binding] GO:0046784 [viral mRNA export from host cell nucleus] GO:2000002 [negative regulation of DNA damage checkpoint] Show all	428 aa 49 kDa	No	0
DDX39B-006 ENSP00000365347 ENST00000376177	Q5STU3 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] GO:0008152 [metabolic process] Show all	425 aa 48.8 kDa	No	0
DDX39B-009 ENSP00000392672 ENST00000428098	F6TRA5 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	238 aa 26.7 kDa	No	0
DDX39B-010 ENSP00000405245 ENST00000419020	F6S2B7 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	132 aa 14.3 kDa	No	0
DDX39B-011 ENSP00000399841 ENST00000418897	F6SXL5 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	136 aa 14.7 kDa	No	0
DDX39B-012 ENSP00000393984 ENST00000456976	F6U6E2 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	125 aa 13.5 kDa	No	0
DDX39B-013 ENSP00000405707 ENST00000428450	F6R6M7 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	197 aa 21.9 kDa	No	0
DDX39B-014 ENSP00000416350 ENST00000456662	F6S4E6 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	231 aa 25.9 kDa	No	0
DDX39B-016 ENSP00000409426 ENST00000449757	F6QYI9 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	187 aa 20.5 kDa	No	0
DDX39B-017 ENSP00000399371 ENST00000427214	F6WLT2 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] Show all	289 aa 32.9 kDa	No	0
DDX39B-018 ENSP00000410313 ENST00000419338	A0A0A0MT12 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0006974 [cellular response to DNA damage stimulus] Show all	236 aa 26.5 kDa	No	0
DDX39B-019 ENSP00000408000 ENST00000431908	F6UJC5 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0006974 [cellular response to DNA damage stimulus] Show all	245 aa 28.3 kDa	No	0
DDX39B-020 ENSP00000406422 ENST00000417023	H0Y400 [Direct mapping] Spliceosome RNA helicase DDX39B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006974 [cellular response to DNA damage stimulus] Show all	187 aa 21.7 kDa	No	0

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