Cell atlas - SPANXC - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SPANXC
Gene description	SPANX family, member C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (A-431, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046423
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA046423	A-431	Nucleoplasm
HPA046423	A549	Nucleoplasm
HPA046423	U-2 OS	Nucleoplasm
HPA046423	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SPANXC (HGNC Symbol)
Synonyms	CT11.3, CTp11
Description	SPANX family, member C (HGNC Symbol)
Entrez gene summary	Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q27.2
Chromosome location (bp)	141241463 - 141242496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198573 (version 83.38)
Entrez gene	64663
UniProt	Q9NY87 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY87
Antibodypedia	SPANXC antibodies

PROTEIN BROWSER

SPANXC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPANXC-001 ENSP00000351884 ENST00000358993	Q9NY87 [Direct mapping] Sperm protein associated with the nucleus on the X chromosome C Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008150 [biological_process] Show all	97 aa 11 kDa	No	0