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Most of the malignant cells displayed weak to moderate membranous and/or cytoplasmic staining with additional nuclear immunoreactivity in some cases. A few non-Hodgkins lymphomas, colorectal, ovarian and urothelial cancers were strongly stained. Many malignant gliomas, breast, prostate, endometrial and renal cancers were negative.
GENE INFORMATION
Gene name
SPANXC (HGNC Symbol)
Synonyms
CT11.3, CTp11
Description
SPANX family, member C (HGNC Symbol)
Entrez gene summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]