Tissue expression of PAPSS2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PAPSS2
Gene description	3'-phosphoadenosine 5'-phosphosulfate synthase 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PAPSS2 (HGNC Symbol)
Synonyms	ATPSK2
Description	3'-phosphoadenosine 5'-phosphosulfate synthase 2 (HGNC Symbol)
Entrez gene summary	Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband
Chromosome location (bp)	87659613 - 87747705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198682 (version 83.38)
Entrez gene	9060
UniProt	O95340 (UniProt - Evidence at protein level)
neXtProt	NX_O95340
Antibodypedia	PAPSS2 antibodies

PROTEIN BROWSER

PAPSS2-001	PAPSS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPSS2-001 ENSP00000354436 ENST00000361175	O95340 [Direct mapping] Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase Q5TB52 [Target identity:100%; Query identity:100%] 3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b; cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNA Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0001501 [skeletal system development] GO:0004020 [adenylylsulfate kinase activity] GO:0004781 [sulfate adenylyltransferase (ATP) activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016310 [phosphorylation] GO:0016779 [nucleotidyltransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] Show all	614 aa 69.5 kDa	No	0
PAPSS2-201 ENSP00000406157 ENST00000456849	O95340 [Direct mapping] Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0001501 [skeletal system development] GO:0004020 [adenylylsulfate kinase activity] GO:0004781 [sulfate adenylyltransferase (ATP) activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007596 [blood coagulation] GO:0016310 [phosphorylation] GO:0016779 [nucleotidyltransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] GO:0060348 [bone development] Show all	619 aa 70 kDa	No	0