Cell atlas - SLC9A6 - The Human Protein Atlas

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SLC9A6

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC9A6
Gene description	Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059590
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059590	A-431	Vesicles
	HPA059590	RH-30	Vesicles
	HPA059590	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SLC9A6 (HGNC Symbol)
Synonyms	KIAA0267, NHE6
Description	Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Chromosome	X
Cytoband	q26.3
Chromosome location (bp)	135985424 - 136047269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198689 (version 83.38)
Entrez gene	10479
UniProt	Q92581 (UniProt - Evidence at protein level)
neXtProt	NX_Q92581
Antibodypedia	SLC9A6 antibodies

PROTEIN BROWSER

SLC9A6-001	SLC9A6-002	SLC9A6-003	SLC9A6-004	SLC9A6-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A6-001 ENSP00000359732 ENST00000370698	Q92581 [Direct mapping] Sodium/hydrogen exchanger 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031901 [early endosome membrane] GO:0035725 [sodium ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0048675 [axon extension] GO:0048812 [neuron projection morphogenesis] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0097484 [dendrite extension] GO:1902600 [hydrogen ion transmembrane transport] Show all	669 aa 74.2 kDa	Yes	>9
SLC9A6-002 ENSP00000359729 ENST00000370695	Q92581 [Direct mapping] Sodium/hydrogen exchanger 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0031410 [cytoplasmic vesicle] GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway] GO:0031901 [early endosome membrane] GO:0035725 [sodium ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043679 [axon terminus] GO:0044308 [axonal spine] GO:0045202 [synapse] GO:0048675 [axon extension] GO:0048812 [neuron projection morphogenesis] GO:0050808 [synapse organization] GO:0051386 [regulation of neurotrophin TRK receptor signaling pathway] GO:0055037 [recycling endosome] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0060996 [dendritic spine development] GO:0097484 [dendrite extension] GO:1902600 [hydrogen ion transmembrane transport] Show all	701 aa 77.9 kDa	Yes	>9
SLC9A6-003 ENSP00000359735 ENST00000370701	Q92581 [Direct mapping] Sodium/hydrogen exchanger 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031901 [early endosome membrane] GO:0035725 [sodium ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0048675 [axon extension] GO:0048812 [neuron projection morphogenesis] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0097484 [dendrite extension] GO:1902600 [hydrogen ion transmembrane transport] Show all	649 aa 72.3 kDa	No	>9
SLC9A6-004 ENSP00000486743 ENST00000627534	A0A0D9SFM4 [Direct mapping] Sodium/hydrogen exchanger Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	184 aa 21 kDa	No	4
SLC9A6-005 ENSP00000487486 ENST00000630721	A0A0D9SGH0 [Direct mapping] Sodium/hydrogen exchanger 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015299 [solute:proton antiporter activity] GO:0016021 [integral component of membrane] GO:1902600 [hydrogen ion transmembrane transport] Show all	207 aa 23.3 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.