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SLC9A6

GENERAL INFORMATION

Gene name

 SLC9A6

Gene description

 Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues. Highest expression in the brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA059445 , HPA059590
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059445
HPA059590

GENE INFORMATION

Gene name

 SLC9A6 (HGNC Symbol)

Synonyms

 KIAA0267, NHE6

Description

 Solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Chromosome

 X

Cytoband

 q26.3

Chromosome location (bp)

 135985424 - 136047269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198689 (version 83.38)

Entrez gene

 10479

UniProt

 Q92581 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92581

Antibodypedia

 SLC9A6 antibodies

PROTEIN BROWSER
SLC9A6-001
SLC9A6-002
SLC9A6-003
SLC9A6-004
SLC9A6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC9A6-001
ENSP00000359732
ENST00000370698
Q92581 [Direct mapping]
Sodium/hydrogen exchanger 6
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0031901 [early endosome membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048675 [axon extension]
GO:0048812 [neuron projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0097484 [dendrite extension]
GO:1902600 [hydrogen ion transmembrane transport]
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 669 aa
74.2 kDa 		Yes >9
SLC9A6-002
ENSP00000359729
ENST00000370695
Q92581 [Direct mapping]
Sodium/hydrogen exchanger 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0031410 [cytoplasmic vesicle]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031901 [early endosome membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043679 [axon terminus]
GO:0044308 [axonal spine]
GO:0045202 [synapse]
GO:0048675 [axon extension]
GO:0048812 [neuron projection morphogenesis]
GO:0050808 [synapse organization]
GO:0051386 [regulation of neurotrophin TRK receptor signaling pathway]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0060996 [dendritic spine development]
GO:0097484 [dendrite extension]
GO:1902600 [hydrogen ion transmembrane transport]
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 701 aa
77.9 kDa 		Yes >9
SLC9A6-003
ENSP00000359735
ENST00000370701
Q92581 [Direct mapping]
Sodium/hydrogen exchanger 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0031901 [early endosome membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048675 [axon extension]
GO:0048812 [neuron projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0097484 [dendrite extension]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 649 aa
72.3 kDa 		No >9
SLC9A6-004
ENSP00000486743
ENST00000627534
A0A0D9SFM4 [Direct mapping]
Sodium/hydrogen exchanger
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006812 [cation transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 184 aa
21 kDa 		No 4
SLC9A6-005
ENSP00000487486
ENST00000630721
A0A0D9SGH0 [Direct mapping]
Sodium/hydrogen exchanger 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015299 [solute:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 207 aa
23.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.