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MT-CO2

GENERAL INFORMATION

Gene name

 MT-CO2

Gene description

 Mitochondrially encoded cytochrome c oxidase II

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA051505 , HPA054758 , CAB016243
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA051505
HPA054758
CAB016243

GENE INFORMATION

Gene name

 MT-CO2 (HGNC Symbol)

Synonyms

 CO2, COX2, MTCO2

Description

 Mitochondrially encoded cytochrome c oxidase II (HGNC Symbol)

Entrez gene summary

Chromosome

 MT

Cytoband

Chromosome location (bp)

 7586 - 8269

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198712 (version 83.38)

Entrez gene

 4513

UniProt

 P00403 (UniProt - Evidence at protein level)

neXtProt

 NX_P00403

Antibodypedia

 MT-CO2 antibodies

PROTEIN BROWSER
MT-CO2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MT-CO2-201
ENSP00000354876
ENST00000361739
P00403 [Direct mapping]
Cytochrome c oxidase subunit 2
U5Z487 [Target identity:100%; Query identity:100%]
Cytochrome c oxidase subunit 2
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0004129 [cytochrome-c oxidase activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007595 [lactation]
GO:0009409 [response to cold]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0022900 [electron transport chain]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045277 [respiratory chain complex IV]
GO:0070062 [extracellular exosome]
GO:1902600 [hydrogen ion transmembrane transport]
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 227 aa
25.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.