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Majority of cancer tissues showed weak to moderate cytoplasmic positivity. Few prostate, lung and pancreatic cancers showed strong immunoreactivity. Lymphomas were mainly negative.
GENE INFORMATION
Gene name
MTOR (HGNC Symbol)
Synonyms
FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Description
Mechanistic target of rapamycin (serine/threonine kinase) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000724 [double-strand break repair via homologous recombination] GO:0001030 [RNA polymerase III type 1 promoter DNA binding] GO:0001031 [RNA polymerase III type 2 promoter DNA binding] GO:0001032 [RNA polymerase III type 3 promoter DNA binding] GO:0001156 [TFIIIC-class transcription factor binding] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0003007 [heart morphogenesis] GO:0003179 [heart valve morphogenesis] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006109 [regulation of carbohydrate metabolic process] GO:0006112 [energy reserve metabolic process] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007050 [cell cycle arrest] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007281 [germ cell development] GO:0007420 [brain development] GO:0007569 [cell aging] GO:0007584 [response to nutrient] GO:0007616 [long-term memory] GO:0008144 [drug binding] GO:0008286 [insulin receptor signaling pathway] GO:0008542 [visual learning] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009791 [post-embryonic development] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0010942 [positive regulation of cell death] GO:0010976 [positive regulation of neuron projection development] GO:0012505 [endomembrane system] GO:0014042 [positive regulation of neuron maturation] GO:0014736 [negative regulation of muscle atrophy] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016236 [macroautophagy] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016605 [PML body] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0021510 [spinal cord development] GO:0030030 [cell projection organization] GO:0030163 [protein catabolic process] GO:0030425 [dendrite] GO:0030838 [positive regulation of actin filament polymerization] GO:0031295 [T cell costimulation] GO:0031397 [negative regulation of protein ubiquitination] GO:0031529 [ruffle organization] GO:0031641 [regulation of myelination] GO:0031669 [cellular response to nutrient levels] GO:0031929 [TOR signaling] GO:0031931 [TORC1 complex] GO:0031932 [TORC2 complex] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0032095 [regulation of response to food] GO:0032868 [response to insulin] GO:0032956 [regulation of actin cytoskeleton organization] GO:0032991 [macromolecular complex] GO:0034605 [cellular response to heat] GO:0035176 [social behavior] GO:0035264 [multicellular organism growth] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0040007 [growth] GO:0042060 [wound healing] GO:0042220 [response to cocaine] GO:0043022 [ribosome binding] GO:0043025 [neuronal cell body] GO:0043087 [regulation of GTPase activity] GO:0043200 [response to amino acid] GO:0043278 [response to morphine] GO:0043610 [regulation of carbohydrate utilization] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045670 [regulation of osteoclast differentiation] GO:0045727 [positive regulation of translation] GO:0045792 [negative regulation of cell size] GO:0045859 [regulation of protein kinase activity] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048255 [mRNA stabilization] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048714 [positive regulation of oligodendrocyte differentiation] GO:0048738 [cardiac muscle tissue development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050769 [positive regulation of neurogenesis] GO:0050882 [voluntary musculoskeletal movement] GO:0051219 [phosphoprotein binding] GO:0051496 [positive regulation of stress fiber assembly] GO:0051534 [negative regulation of NFAT protein import into nucleus] GO:0051896 [regulation of protein kinase B signaling] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055006 [cardiac cell development] GO:0055013 [cardiac muscle cell development] GO:0060048 [cardiac muscle contraction] GO:0060135 [maternal process involved in female pregnancy] GO:0060252 [positive regulation of glial cell proliferation] GO:0060999 [positive regulation of dendritic spine development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0071456 [cellular response to hypoxia] GO:0090335 [regulation of brown fat cell differentiation] GO:0090559 [regulation of membrane permeability] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1903147 [negative regulation of mitophagy] GO:1904000 [positive regulation of eating behavior] GO:1904056 [positive regulation of cholangiocyte proliferation] GO:1904058 [positive regulation of sensory perception of pain] GO:1904193 [negative regulation of cholangiocyte apoptotic process] GO:1904197 [positive regulation of granulosa cell proliferation] GO:1904206 [positive regulation of skeletal muscle hypertrophy] GO:1904213 [negative regulation of iodide transmembrane transport]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)