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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MTOR
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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MTOR

Gene description

Mechanistic target of rapamycin (serine/threonine kinase)

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB069425
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB069425

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Majority of cancer tissues showed weak to moderate cytoplasmic positivity. Few prostate, lung and pancreatic cancers showed strong immunoreactivity. Lymphomas were mainly negative.

GENE INFORMATION

Gene name

MTOR (HGNC Symbol)

Synonyms

FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Description

Mechanistic target of rapamycin (serine/threonine kinase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

11106535 - 11262507

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198793 (version 83.38)

Entrez gene

2475

UniProt

P42345 (UniProt - Evidence at protein level)

neXtProt

NX_P42345

Antibodypedia

MTOR antibodies

PROTEIN BROWSER

MTOR-001
MTOR-002
MTOR-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTOR-001
ENSP00000354558
ENST00000361445
P42345 [Direct mapping]
Serine/threonine-protein kinase mTOR
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001030 [RNA polymerase III type 1 promoter DNA binding]
GO:0001031 [RNA polymerase III type 2 promoter DNA binding]
GO:0001032 [RNA polymerase III type 3 promoter DNA binding]
GO:0001156 [TFIIIC-class transcription factor binding]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003007 [heart morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005979 [regulation of glycogen biosynthetic process]
GO:0006109 [regulation of carbohydrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0007420 [brain development]
GO:0007569 [cell aging]
GO:0007584 [response to nutrient]
GO:0007616 [long-term memory]
GO:0008144 [drug binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008542 [visual learning]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009791 [post-embryonic development]
GO:0010467 [gene expression]
GO:0010507 [negative regulation of autophagy]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010628 [positive regulation of gene expression]
GO:0010831 [positive regulation of myotube differentiation]
GO:0010942 [positive regulation of cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0012505 [endomembrane system]
GO:0014042 [positive regulation of neuron maturation]
GO:0014736 [negative regulation of muscle atrophy]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016236 [macroautophagy]
GO:0016242 [negative regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016605 [PML body]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021510 [spinal cord development]
GO:0030030 [cell projection organization]
GO:0030163 [protein catabolic process]
GO:0030425 [dendrite]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031529 [ruffle organization]
GO:0031641 [regulation of myelination]
GO:0031669 [cellular response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0031931 [TORC1 complex]
GO:0031932 [TORC2 complex]
GO:0031998 [regulation of fatty acid beta-oxidation]
GO:0032095 [regulation of response to food]
GO:0032868 [response to insulin]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0032991 [macromolecular complex]
GO:0034605 [cellular response to heat]
GO:0035176 [social behavior]
GO:0035264 [multicellular organism growth]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040007 [growth]
GO:0042060 [wound healing]
GO:0042220 [response to cocaine]
GO:0043022 [ribosome binding]
GO:0043025 [neuronal cell body]
GO:0043087 [regulation of GTPase activity]
GO:0043200 [response to amino acid]
GO:0043278 [response to morphine]
GO:0043610 [regulation of carbohydrate utilization]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045727 [positive regulation of translation]
GO:0045792 [negative regulation of cell size]
GO:0045859 [regulation of protein kinase activity]
GO:0045945 [positive regulation of transcription from RNA polymerase III promoter]
GO:0046777 [protein autophosphorylation]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0046983 [protein dimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048255 [mRNA stabilization]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0048738 [cardiac muscle tissue development]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050769 [positive regulation of neurogenesis]
GO:0050882 [voluntary musculoskeletal movement]
GO:0051219 [phosphoprotein binding]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051534 [negative regulation of NFAT protein import into nucleus]
GO:0051896 [regulation of protein kinase B signaling]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055006 [cardiac cell development]
GO:0055013 [cardiac muscle cell development]
GO:0060048 [cardiac muscle contraction]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060252 [positive regulation of glial cell proliferation]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development]
GO:0071456 [cellular response to hypoxia]
GO:0090335 [regulation of brown fat cell differentiation]
GO:0090559 [regulation of membrane permeability]
GO:1900034 [regulation of cellular response to heat]
GO:1901216 [positive regulation of neuron death]
GO:1903147 [negative regulation of mitophagy]
GO:1904000 [positive regulation of eating behavior]
GO:1904056 [positive regulation of cholangiocyte proliferation]
GO:1904058 [positive regulation of sensory perception of pain]
GO:1904193 [negative regulation of cholangiocyte apoptotic process]
GO:1904197 [positive regulation of granulosa cell proliferation]
GO:1904206 [positive regulation of skeletal muscle hypertrophy]
GO:1904213 [negative regulation of iodide transmembrane transport]
Show all
2549 aa
288.9 kDa
No 0
MTOR-002
ENSP00000366034
ENST00000376838
B1AKP8 [Direct mapping]
Serine/threonine-protein kinase mTOR
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008144 [drug binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0046983 [protein dimerization activity]
Show all
754 aa
85.9 kDa
No 0
MTOR-005
ENSP00000398745
ENST00000455339
B1AKQ2 [Direct mapping]
Serine/threonine-protein kinase mTOR
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0046983 [protein dimerization activity]
Show all
161 aa
18.2 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.