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Mechanistic target of rapamycin (serine/threonine kinase) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000724 [double-strand break repair via homologous recombination] GO:0001030 [RNA polymerase III type 1 promoter DNA binding] GO:0001031 [RNA polymerase III type 2 promoter DNA binding] GO:0001032 [RNA polymerase III type 3 promoter DNA binding] GO:0001156 [TFIIIC-class transcription factor binding] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0003007 [heart morphogenesis] GO:0003179 [heart valve morphogenesis] GO:0004674 [protein serine/threonine kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006109 [regulation of carbohydrate metabolic process] GO:0006112 [energy reserve metabolic process] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007050 [cell cycle arrest] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007281 [germ cell development] GO:0007420 [brain development] GO:0007569 [cell aging] GO:0007584 [response to nutrient] GO:0007616 [long-term memory] GO:0008144 [drug binding] GO:0008286 [insulin receptor signaling pathway] GO:0008542 [visual learning] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009791 [post-embryonic development] GO:0010467 [gene expression] GO:0010507 [negative regulation of autophagy] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0010942 [positive regulation of cell death] GO:0010976 [positive regulation of neuron projection development] GO:0012505 [endomembrane system] GO:0014042 [positive regulation of neuron maturation] GO:0014736 [negative regulation of muscle atrophy] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016236 [macroautophagy] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016605 [PML body] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0021510 [spinal cord development] GO:0030030 [cell projection organization] GO:0030163 [protein catabolic process] GO:0030425 [dendrite] GO:0030838 [positive regulation of actin filament polymerization] GO:0031295 [T cell costimulation] GO:0031397 [negative regulation of protein ubiquitination] GO:0031529 [ruffle organization] GO:0031641 [regulation of myelination] GO:0031669 [cellular response to nutrient levels] GO:0031929 [TOR signaling] GO:0031931 [TORC1 complex] GO:0031932 [TORC2 complex] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0032095 [regulation of response to food] GO:0032868 [response to insulin] GO:0032956 [regulation of actin cytoskeleton organization] GO:0032991 [macromolecular complex] GO:0034605 [cellular response to heat] GO:0035176 [social behavior] GO:0035264 [multicellular organism growth] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0040007 [growth] GO:0042060 [wound healing] GO:0042220 [response to cocaine] GO:0043022 [ribosome binding] GO:0043025 [neuronal cell body] GO:0043087 [regulation of GTPase activity] GO:0043200 [response to amino acid] GO:0043278 [response to morphine] GO:0043610 [regulation of carbohydrate utilization] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045670 [regulation of osteoclast differentiation] GO:0045727 [positive regulation of translation] GO:0045792 [negative regulation of cell size] GO:0045859 [regulation of protein kinase activity] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048255 [mRNA stabilization] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048714 [positive regulation of oligodendrocyte differentiation] GO:0048738 [cardiac muscle tissue development] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050769 [positive regulation of neurogenesis] GO:0050882 [voluntary musculoskeletal movement] GO:0051219 [phosphoprotein binding] GO:0051496 [positive regulation of stress fiber assembly] GO:0051534 [negative regulation of NFAT protein import into nucleus] GO:0051896 [regulation of protein kinase B signaling] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055006 [cardiac cell development] GO:0055013 [cardiac muscle cell development] GO:0060048 [cardiac muscle contraction] GO:0060135 [maternal process involved in female pregnancy] GO:0060252 [positive regulation of glial cell proliferation] GO:0060999 [positive regulation of dendritic spine development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0071456 [cellular response to hypoxia] GO:0090335 [regulation of brown fat cell differentiation] GO:0090559 [regulation of membrane permeability] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1903147 [negative regulation of mitophagy] GO:1904000 [positive regulation of eating behavior] GO:1904056 [positive regulation of cholangiocyte proliferation] GO:1904058 [positive regulation of sensory perception of pain] GO:1904193 [negative regulation of cholangiocyte apoptotic process] GO:1904197 [positive regulation of granulosa cell proliferation] GO:1904206 [positive regulation of skeletal muscle hypertrophy] GO:1904213 [negative regulation of iodide transmembrane transport]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)