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GRM3

GENERAL INFORMATION

Gene name

 GRM3

Gene description

 Glutamate receptor, metabotropic 3

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (AF22)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GRM3 (HGNC Symbol)

Synonyms

 GPRC1C, mGlu3, MGLUR3

Description

 Glutamate receptor, metabotropic 3 (HGNC Symbol)

Entrez gene summary

 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

Chromosome location (bp)

 86643914 - 86864884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198822 (version 83.38)

Entrez gene

 2913

UniProt

 Q14832 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14832

Antibodypedia

 GRM3 antibodies

PROTEIN BROWSER
GRM3-001
GRM3-002
GRM3-003
GRM3-004
GRM3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRM3-001
ENSP00000355316
ENST00000361669
Q14832 [Direct mapping]
Metabotropic glutamate receptor 3
A4D1D0 [Target identity:100%; Query identity:100%]
Glutamate metabotropic receptor 3; Glutamate receptor, metabotropic 3; Glutamate receptor, metabotropic 3, isoform CRA_b
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   Family 3 (C) receptors
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001641 [group II metabotropic glutamate receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005246 [calcium channel regulator activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0045211 [postsynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
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 879 aa
98.9 kDa 		Yes 7
GRM3-002
ENSP00000390037
ENST00000421579
C9JIT1 [Direct mapping]
Metabotropic glutamate receptor 3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001641 [group II metabotropic glutamate receptor activity]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0042734 [presynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
Show all
 87 aa
9.9 kDa 		Yes 0
GRM3-003
ENSP00000407490
ENST00000441140
C9JUH9 [Direct mapping]
Metabotropic glutamate receptor 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001641 [group II metabotropic glutamate receptor activity]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0042734 [presynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
Show all
 81 aa
9.1 kDa 		Yes 0
GRM3-004
ENSP00000405427
ENST00000454217
C9J2I2 [Direct mapping]
Metabotropic glutamate receptor 3
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Predicted intracellular proteins
Show all
GO:0001641 [group II metabotropic glutamate receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0042734 [presynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
Show all
 171 aa
19 kDa 		No 0
GRM3-005
ENSP00000398767
ENST00000439827
Q14832 [Direct mapping]
Metabotropic glutamate receptor 3
Show all
   Family 3 (C) receptors
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001641 [group II metabotropic glutamate receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008066 [glutamate receptor activity]
GO:0016021 [integral component of membrane]
GO:0042734 [presynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
Show all
 537 aa
60.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.