Tissue expression of GRM3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GRM3
Gene description	Glutamate receptor, metabotropic 3
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	GRM3 (HGNC Symbol)
Synonyms	GPRC1C, mGlu3, MGLUR3
Description	Glutamate receptor, metabotropic 3 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband
Chromosome location (bp)	86643914 - 86864884
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198822 (version 83.38)
Entrez gene	2913
UniProt	Q14832 (UniProt - Evidence at protein level)
neXtProt	NX_Q14832
Antibodypedia	GRM3 antibodies

PROTEIN BROWSER

GRM3-001	GRM3-002	GRM3-003	GRM3-004	GRM3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM3-001 ENSP00000355316 ENST00000361669	Q14832 [Direct mapping] Metabotropic glutamate receptor 3 A4D1D0 [Target identity:100%; Query identity:100%] Glutamate metabotropic receptor 3; Glutamate receptor, metabotropic 3; Glutamate receptor, metabotropic 3, isoform CRA_b Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0043197 [dendritic spine] GO:0045211 [postsynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	879 aa 98.9 kDa	Yes	7
GRM3-002 ENSP00000390037 ENST00000421579	C9JIT1 [Direct mapping] Metabotropic glutamate receptor 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	87 aa 9.9 kDa	Yes	0
GRM3-003 ENSP00000407490 ENST00000441140	C9JUH9 [Direct mapping] Metabotropic glutamate receptor 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	81 aa 9.1 kDa	Yes	0
GRM3-004 ENSP00000405427 ENST00000454217	C9J2I2 [Direct mapping] Metabotropic glutamate receptor 3 Show all	Predicted intracellular proteins Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	171 aa 19 kDa	No	0
GRM3-005 ENSP00000398767 ENST00000439827	Q14832 [Direct mapping] Metabotropic glutamate receptor 3 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001641 [group II metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	537 aa 60.7 kDa	Yes	0