Expression of HMGN2 in cancer - Summary - The Human Protein Atlas

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HMGN2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HMGN2
Gene description	High mobility group nucleosomal binding domain 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB018371
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB018371

GENE INFORMATION
Gene name	HMGN2 (HGNC Symbol)
Synonyms	HMG17
Description	High mobility group nucleosomal binding domain 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	26472450 - 26475972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198830 (version 83.38)
Entrez gene	3151
UniProt	P05204 (UniProt - Evidence at protein level)
neXtProt	NX_P05204
Antibodypedia	HMGN2 antibodies

PROTEIN BROWSER

HMGN2-001	HMGN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMGN2-001 ENSP00000355228 ENST00000361427	P05204 [Direct mapping] Non-histone chromosomal protein HMG-17 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031492 [nucleosomal DNA binding] GO:0044822 [poly(A) RNA binding] Show all	90 aa 9.4 kDa	No	0
HMGN2-201 ENSP00000481160 ENST00000619352	P05204 [Direct mapping] Non-histone chromosomal protein HMG-17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031492 [nucleosomal DNA binding] GO:0044822 [poly(A) RNA binding] Show all	90 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.