Tissue expression of HMGN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HMGN2
Gene description	High mobility group nucleosomal binding domain 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB018371
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HMGN2 (HGNC Symbol)
Synonyms	HMG17
Description	High mobility group nucleosomal binding domain 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	26472450 - 26475972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198830 (version 83.38)
Entrez gene	3151
UniProt	P05204 (UniProt - Evidence at protein level)
neXtProt	NX_P05204
Antibodypedia	HMGN2 antibodies

PROTEIN BROWSER

HMGN2-001	HMGN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMGN2-001 ENSP00000355228 ENST00000361427	P05204 [Direct mapping] Non-histone chromosomal protein HMG-17 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031492 [nucleosomal DNA binding] GO:0044822 [poly(A) RNA binding] Show all	90 aa 9.4 kDa	No	0
HMGN2-201 ENSP00000481160 ENST00000619352	P05204 [Direct mapping] Non-histone chromosomal protein HMG-17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031492 [nucleosomal DNA binding] GO:0044822 [poly(A) RNA binding] Show all	90 aa 9.4 kDa	No	0