Cell atlas - TOX - The Human Protein Atlas

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TOX

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TOX
Gene description	Thymocyte selection-associated high mobility group box
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (MOLT-4, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA073241
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli (fibrillar center).

Main location

Nucleus (approved), Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA073241	RH-30	Nucleus
	HPA073241	RH-30	Nucleoli fibrillar center
	HPA073241	U-2 OS	Nucleus

GENE INFORMATION
Gene name	TOX (HGNC Symbol)
Synonyms	KIAA0808, TOX1
Description	Thymocyte selection-associated high mobility group box (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	58805418 - 59119208
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198846 (version 83.38)
Entrez gene	9760
UniProt	O94900 (UniProt - Evidence at transcript level)
neXtProt	NX_O94900
Antibodypedia	TOX antibodies

PROTEIN BROWSER

TOX-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOX-001 ENSP00000354842 ENST00000361421	O94900 [Direct mapping] Thymocyte selection-associated high mobility group box protein TOX Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	526 aa 57.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.