Expression of CES1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CES1
Gene description	Carboxylesterase 1
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Group enriched (Hep G2, THP-1, U-937)
HPA (normal tissue):	Group enriched (gallbladder, liver, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in liver and gall bladder as well as in lung and subsets of cells in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012023 , HPA046717
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA012023	HPA046717

GENE INFORMATION
Gene name	CES1 (HGNC Symbol)
Synonyms	CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, SES1
Description	Carboxylesterase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55802851 - 55833337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198848 (version 83.38)
Entrez gene	1066
UniProt	P23141 (UniProt - Evidence at protein level)
neXtProt	NX_P23141
Antibodypedia	CES1 antibodies

PROTEIN BROWSER

CES1-001	CES1-002	CES1-004	CES1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CES1-001 ENSP00000390492 ENST00000422046	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	566 aa 62.4 kDa	Yes	0
CES1-002 ENSP00000353720 ENST00000360526	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	568 aa 62.6 kDa	Yes	0
CES1-004 ENSP00000355193 ENST00000361503	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	567 aa 62.5 kDa	Yes	0
CES1-010 ENSP00000455959 ENST00000563241	H3BQV8 [Direct mapping] Liver carboxylesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.9 kDa	No	0