Tissue expression of CES1 - Summary - The Human Protein Atlas

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CES1

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CES1
Gene description	Carboxylesterase 1
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (gallbladder, liver, lung)
GTEx:	Tissue enhanced (liver)
FANTOM5:	Group enriched (gallbladder, liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct cytoplasmic expression in liver and gall bladder as well as in lung and subsets of cells in gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012023 , HPA046717
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (gallbladder, liver, lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (gallbladder, liver)

GENE INFORMATION
Gene name	CES1 (HGNC Symbol)
Synonyms	CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, SES1
Description	Carboxylesterase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55802851 - 55833337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198848 (version 83.38)
Entrez gene	1066
UniProt	P23141 (UniProt - Evidence at protein level)
neXtProt	NX_P23141
Antibodypedia	CES1 antibodies

PROTEIN BROWSER

CES1-001	CES1-002	CES1-004	CES1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CES1-001 ENSP00000390492 ENST00000422046	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	566 aa 62.4 kDa	Yes	0
CES1-002 ENSP00000353720 ENST00000360526	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	568 aa 62.6 kDa	Yes	0
CES1-004 ENSP00000355193 ENST00000361503	P23141 [Direct mapping] Liver carboxylesterase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0016042 [lipid catabolic process] GO:0030855 [epithelial cell differentiation] GO:0044281 [small molecule metabolic process] GO:0047374 [methylumbelliferyl-acetate deacetylase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	567 aa 62.5 kDa	Yes	0
CES1-010 ENSP00000455959 ENST00000563241	H3BQV8 [Direct mapping] Liver carboxylesterase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.