Cell atlas - TYW1 - The Human Protein Atlas

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TYW1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TYW1
Gene description	TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA014118 , HPA052097
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014118	A549	Nucleus
	HPA014118	A549	Nucleoli
	HPA014118	CACO-2	Nucleus
	HPA014118	CACO-2	Nucleoli
	HPA014118	U-2 OS	Nucleus
	HPA014118	U-2 OS	Nucleoli
	HPA052097	A-431	Nucleus
	HPA052097	A-431	Nucleoli
	HPA052097	U-2 OS	Nucleus
	HPA052097	U-2 OS	Nucleoli	Intensity
	HPA052097	U-251 MG	Nucleus
	HPA052097	U-251 MG	Nucleoli	Intensity

GENE INFORMATION
Gene name	TYW1 (HGNC Symbol)
Synonyms	FLJ10900, MGC23001, MGC60291, RSAFD1, TYW1A, YPL207W
Description	TRNA-yW synthesizing protein 1 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. [provided by RefSeq, Dec 2012]
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	66995173 - 67239519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198874 (version 83.38)
Entrez gene	55253
UniProt	Q9NV66 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NV66
Antibodypedia	TYW1 antibodies

PROTEIN BROWSER

TYW1-001	TYW1-010	TYW1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TYW1-001 ENSP00000352645 ENST00000359626	Q9NV66 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005506 [iron ion binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0010181 [FMN binding] GO:0010467 [gene expression] GO:0016829 [lyase activity] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	732 aa 83.7 kDa	No	1
TYW1-010 ENSP00000398897 ENST00000442959	C9J9Q4 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0010181 [FMN binding] GO:0016021 [integral component of membrane] Show all	134 aa 15 kDa	No	1
TYW1-201 ENSP00000478959 ENST00000615572	A0A087WUV9 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016021 [integral component of membrane] GO:0051536 [iron-sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	668 aa 76.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.