Expression of TYW1 in cancer - Summary - The Human Protein Atlas

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TYW1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TYW1
Gene description	TRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 5 antibodies. HPA013568 , HPA015535 , HPA043136 , HPA047029 , HPA047052
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013568	HPA015535	HPA043136	HPA047029	HPA047052

GENE INFORMATION
Gene name	TYW1 (HGNC Symbol)
Synonyms	FLJ10900, MGC23001, MGC60291, RSAFD1, TYW1A, YPL207W
Description	TRNA-yW synthesizing protein 1 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. [provided by RefSeq, Dec 2012]
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	66995173 - 67239519
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198874 (version 83.38)
Entrez gene	55253
UniProt	Q9NV66 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NV66
Antibodypedia	TYW1 antibodies

PROTEIN BROWSER

TYW1-001	TYW1-010	TYW1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TYW1-001 ENSP00000352645 ENST00000359626	Q9NV66 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005506 [iron ion binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0010181 [FMN binding] GO:0010467 [gene expression] GO:0016829 [lyase activity] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	732 aa 83.7 kDa	No	1
TYW1-010 ENSP00000398897 ENST00000442959	C9J9Q4 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0010181 [FMN binding] GO:0016021 [integral component of membrane] Show all	134 aa 15 kDa	No	1
TYW1-201 ENSP00000478959 ENST00000615572	A0A087WUV9 [Direct mapping] S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016021 [integral component of membrane] GO:0051536 [iron-sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	668 aa 76.9 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.