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MT-ND4

GENERAL INFORMATION

Gene name

 MT-ND4

Gene description

 Mitochondrially encoded NADH dehydrogenase 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053928
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA053928

GENE INFORMATION

Gene name

 MT-ND4 (HGNC Symbol)

Synonyms

 LHON, MTND4, NAD4, ND4

Description

 Mitochondrially encoded NADH dehydrogenase 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 MT

Cytoband

Chromosome location (bp)

 10760 - 12137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198886 (version 83.38)

Entrez gene

 4538

UniProt

 P03905 (UniProt - Evidence at protein level)

neXtProt

 NX_P03905

Antibodypedia

 MT-ND4 antibodies

PROTEIN BROWSER
MT-ND4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MT-ND4-201
ENSP00000354961
ENST00000361381
P03905 [Direct mapping]
NADH-ubiquinone oxidoreductase chain 4
H9EC08 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase chain 4
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0007568 [aging]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0022904 [respiratory electron transport chain]
GO:0035094 [response to nicotine]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0055114 [oxidation-reduction process]
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 459 aa
51.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.