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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MT-ND4
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MT-ND4

Gene description

Mitochondrially encoded NADH dehydrogenase 4

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA053928
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PROGNOSTIC SUMMARY

Prognostic marker in ovarian cancer (favourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 9101112131415 Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all
0.010k20k30k40k50k60k70k80kFPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA053928

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Prostate, ovarian and thyroid cancers and a few cases of melanomas, colorectal, breast, endometrial and urothelial cancers displayed weak to moderate cytoplasmic positivity. Additional nucleolar positivity in a few cases. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

MT-ND4 (HGNC Symbol)

Synonyms

LHON, MTND4, NAD4, ND4

Description

Mitochondrially encoded NADH dehydrogenase 4 (HGNC Symbol)

Entrez gene summary

Chromosome

MT

Cytoband

Chromosome location (bp)

10760 - 12137

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198886 (version 83.38)

Entrez gene

4538

UniProt

P03905 (UniProt - Evidence at protein level)

neXtProt

NX_P03905

Antibodypedia

MT-ND4 antibodies

PROTEIN BROWSER

MT-ND4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MT-ND4-201
ENSP00000354961
ENST00000361381
P03905 [Direct mapping]
NADH-ubiquinone oxidoreductase chain 4
H9EC08 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase chain 4
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0007568 [aging]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0022904 [respiratory electron transport chain]
GO:0035094 [response to nicotine]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0055114 [oxidation-reduction process]
Show all
459 aa
51.6 kDa
No >9

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