Fields »
ABOUT
HELP
BLOG
MT-ND4

GENERAL INFORMATION

Gene name

 MT-ND4

Gene description

 Mitochondrially encoded NADH dehydrogenase 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053928
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010,00020,00030,00040,000TPM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05,00010,00015,00020,000Tags Per Million

GENE INFORMATION

Gene name

 MT-ND4 (HGNC Symbol)

Synonyms

 LHON, MTND4, NAD4, ND4

Description

 Mitochondrially encoded NADH dehydrogenase 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 MT

Cytoband

Chromosome location (bp)

 10760 - 12137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198886 (version 83.38)

Entrez gene

 4538

UniProt

 P03905 (UniProt - Evidence at protein level)

neXtProt

 NX_P03905

Antibodypedia

 MT-ND4 antibodies

PROTEIN BROWSER
MT-ND4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MT-ND4-201
ENSP00000354961
ENST00000361381
P03905 [Direct mapping]
NADH-ubiquinone oxidoreductase chain 4
H9EC08 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase chain 4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0007568 [aging]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0022904 [respiratory electron transport chain]
GO:0035094 [response to nicotine]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0055114 [oxidation-reduction process]
Show all
 459 aa
51.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.