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DCLRE1A

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GENERAL INFORMATION

Gene name

 DCLRE1A

Gene description

 DNA cross-link repair 1A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli (fibrillar center) & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nucleoli fibrillar center (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA036907
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli (fibrillar center) & nucleoplasm.

Main location

 Nucleoplasm (supported), Nucleoli fibrillar center (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA036907 A-431 Nucleoplasm
Nucleoli fibrillar center
HPA036907 U-2 OS Nucleoplasm
Nucleoli fibrillar center
HPA036907 U-251 MG Nucleoplasm
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 DCLRE1A (HGNC Symbol)

Synonyms

 hSNM1, KIAA0086, PSO2, SNM1

Description

 DNA cross-link repair 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 113834725 - 113854383

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198924 (version 83.38)

Entrez gene

 9937

UniProt

 Q6PJP8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PJP8

Antibodypedia

 DCLRE1A antibodies

PROTEIN BROWSER
DCLRE1A-001
DCLRE1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCLRE1A-001
ENSP00000358311
ENST00000369305
Q6PJP8 [Direct mapping]
DNA cross-link repair 1A protein
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003684 [damaged DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0007067 [mitotic nuclear division]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0036297 [interstrand cross-link repair]
GO:0051301 [cell division]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 1040 aa
116.4 kDa 		No 0
DCLRE1A-002
ENSP00000355185
ENST00000361384
Q6PJP8 [Direct mapping]
DNA cross-link repair 1A protein
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003684 [damaged DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0007067 [mitotic nuclear division]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0036297 [interstrand cross-link repair]
GO:0051301 [cell division]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 1040 aa
116.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.