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DCLRE1A

GENERAL INFORMATION

Gene name

 DCLRE1A

Gene description

 DNA cross-link repair 1A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036907
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036907

GENE INFORMATION

Gene name

 DCLRE1A (HGNC Symbol)

Synonyms

 hSNM1, KIAA0086, PSO2, SNM1

Description

 DNA cross-link repair 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 113834725 - 113854383

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198924 (version 83.38)

Entrez gene

 9937

UniProt

 Q6PJP8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PJP8

Antibodypedia

 DCLRE1A antibodies

PROTEIN BROWSER
DCLRE1A-001
DCLRE1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCLRE1A-001
ENSP00000358311
ENST00000369305
Q6PJP8 [Direct mapping]
DNA cross-link repair 1A protein
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003684 [damaged DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0007067 [mitotic nuclear division]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0036297 [interstrand cross-link repair]
GO:0051301 [cell division]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 1040 aa
116.4 kDa 		No 0
DCLRE1A-002
ENSP00000355185
ENST00000361384
Q6PJP8 [Direct mapping]
DNA cross-link repair 1A protein
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003684 [damaged DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0007067 [mitotic nuclear division]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0036297 [interstrand cross-link repair]
GO:0051301 [cell division]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 1040 aa
116.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.