Cell atlas - APRT - The Human Protein Atlas

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APRT

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	APRT
Gene description	Adenine phosphoribosyltransferase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA026681
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026681	A-431	Nucleoplasm
	HPA026681	A-431	Cytosol
	HPA026681	U-2 OS	Nucleoplasm
	HPA026681	U-2 OS	Cytosol
	HPA026681	U-251 MG	Nucleoplasm
	HPA026681	U-251 MG	Cytosol

GENE INFORMATION
Gene name	APRT
Synonyms
Description	Adenine phosphoribosyltransferase (HGNC Symbol)
Entrez gene summary	Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	88809339 - 88811944
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198931 (version 83.38)
Entrez gene	353
UniProt	P07741 (UniProt - Evidence at protein level)
neXtProt	NX_P07741
Antibodypedia	APRT antibodies

PROTEIN BROWSER

APRT-001	APRT-002	APRT-007	APRT-008	APRT-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APRT-001 ENSP00000367615 ENST00000378364	P07741 [Direct mapping] Adenine phosphoribosyltransferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002055 [adenine binding] GO:0003999 [adenine phosphoribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006166 [purine ribonucleoside salvage] GO:0006168 [adenine salvage] GO:0007595 [lactation] GO:0007625 [grooming behavior] GO:0009116 [nucleoside metabolic process] GO:0016208 [AMP binding] GO:0032869 [cellular response to insulin stimulus] GO:0043101 [purine-containing compound salvage] GO:0044209 [AMP salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	180 aa 19.6 kDa	No	0
APRT-002 ENSP00000397007 ENST00000426324	P07741 [Direct mapping] Adenine phosphoribosyltransferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003999 [adenine phosphoribosyltransferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0009116 [nucleoside metabolic process] GO:0016208 [AMP binding] GO:0043101 [purine-containing compound salvage] GO:0044209 [AMP salvage] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	134 aa 14.6 kDa	No	0
APRT-007 ENSP00000455749 ENST00000567713	H3BQF1 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	149 aa 16.4 kDa	No	0
APRT-008 ENSP00000455692 ENST00000569616	H3BQB1 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	162 aa 17.5 kDa	No	0
APRT-011 ENSP00000456012 ENST00000563655	H3BQZ9 [Direct mapping] Adenine phosphoribosyltransferase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0009116 [nucleoside metabolic process] GO:0016740 [transferase activity] Show all	153 aa 16.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.