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APRT

GENERAL INFORMATION

Gene name

 APRT

Gene description

 Adenine phosphoribosyltransferase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026681
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026681

GENE INFORMATION

Gene name

 APRT

Synonyms

Description

 Adenine phosphoribosyltransferase (HGNC Symbol)

Entrez gene summary

 Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q24.3

Chromosome location (bp)

 88809339 - 88811944

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198931 (version 83.38)

Entrez gene

 353

UniProt

 P07741 (UniProt - Evidence at protein level)

neXtProt

 NX_P07741

Antibodypedia

 APRT antibodies

PROTEIN BROWSER
APRT-001
APRT-002
APRT-007
APRT-008
APRT-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APRT-001
ENSP00000367615
ENST00000378364
P07741 [Direct mapping]
Adenine phosphoribosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002055 [adenine binding]
GO:0003999 [adenine phosphoribosyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006166 [purine ribonucleoside salvage]
GO:0006168 [adenine salvage]
GO:0007595 [lactation]
GO:0007625 [grooming behavior]
GO:0009116 [nucleoside metabolic process]
GO:0016208 [AMP binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 180 aa
19.6 kDa 		No 0
APRT-002
ENSP00000397007
ENST00000426324
P07741 [Direct mapping]
Adenine phosphoribosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003999 [adenine phosphoribosyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0009116 [nucleoside metabolic process]
GO:0016208 [AMP binding]
GO:0043101 [purine-containing compound salvage]
GO:0044209 [AMP salvage]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 134 aa
14.6 kDa 		No 0
APRT-007
ENSP00000455749
ENST00000567713
H3BQF1 [Direct mapping]
Adenine phosphoribosyltransferase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0009116 [nucleoside metabolic process]
GO:0016740 [transferase activity]
Show all
 149 aa
16.4 kDa 		No 0
APRT-008
ENSP00000455692
ENST00000569616
H3BQB1 [Direct mapping]
Adenine phosphoribosyltransferase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009116 [nucleoside metabolic process]
GO:0016740 [transferase activity]
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 162 aa
17.5 kDa 		No 0
APRT-011
ENSP00000456012
ENST00000563655
H3BQZ9 [Direct mapping]
Adenine phosphoribosyltransferase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0009116 [nucleoside metabolic process]
GO:0016740 [transferase activity]
Show all
 153 aa
16.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.