Expression of GPRASP1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GPRASP1

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPRASP1
Gene description	G protein-coupled receptor associated sorting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression, highly abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA000161
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and thyroid cancer (unfavourable).
Pancreatic cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000161

GENE INFORMATION
Gene name	GPRASP1 (HGNC Symbol)
Synonyms	GASP, GASP1
Description	G protein-coupled receptor associated sorting protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	102651366 - 102659083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198932 (version 83.38)
Entrez gene	9737
UniProt	Q5JY77 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JY77
Antibodypedia	GPRASP1 antibodies

PROTEIN BROWSER

GPRASP1-001	GPRASP1-201	GPRASP1-202	GPRASP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRASP1-001 ENSP00000355146 ENST00000361600	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-201 ENSP00000393691 ENST00000415986	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-202 ENSP00000409420 ENST00000444152	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-203 ENSP00000445683 ENST00000537097	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.