Tissue expression of GPRASP1 - Summary - The Human Protein Atlas

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GPRASP1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GPRASP1
Gene description	G protein-coupled receptor associated sorting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (brain, caudate)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression, highly abundant in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA000161
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, caudate)

GENE INFORMATION
Gene name	GPRASP1 (HGNC Symbol)
Synonyms	GASP, GASP1
Description	G protein-coupled receptor associated sorting protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	102651366 - 102659083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198932 (version 83.38)
Entrez gene	9737
UniProt	Q5JY77 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JY77
Antibodypedia	GPRASP1 antibodies

PROTEIN BROWSER

GPRASP1-001	GPRASP1-201	GPRASP1-202	GPRASP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRASP1-001 ENSP00000355146 ENST00000361600	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-201 ENSP00000393691 ENST00000415986	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-202 ENSP00000409420 ENST00000444152	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0
GPRASP1-203 ENSP00000445683 ENST00000537097	Q5JY77 [Direct mapping] G-protein coupled receptor-associated sorting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008333 [endosome to lysosome transport] GO:1990172 [G-protein coupled receptor catabolic process] Show all	1395 aa 156.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.