Expression of MFAP3L in cancer - Summary - The Human Protein Atlas

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MFAP3L

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MFAP3L
Gene description	Microfibrillar-associated protein 3-like
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, RT4, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA017986
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017986

GENE INFORMATION
Gene name	MFAP3L (HGNC Symbol)
Synonyms	KIAA0626, NYD-sp9
Description	Microfibrillar-associated protein 3-like (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q33
Chromosome location (bp)	169986597 - 170033031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198948 (version 83.38)
Entrez gene	9848
UniProt	O75121 (UniProt - Evidence at transcript level)
neXtProt	NX_O75121
Antibodypedia	MFAP3L antibodies

PROTEIN BROWSER

MFAP3L-001	MFAP3L-002	MFAP3L-003	MFAP3L-004	MFAP3L-006	MFAP3L-007	MFAP3L-008	MFAP3L-009	MFAP3L-010	MFAP3L-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFAP3L-001 ENSP00000354583 ENST00000361618	O75121 [Direct mapping] Microfibrillar-associated protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	409 aa 45.4 kDa	Yes	1
MFAP3L-002 ENSP00000377307 ENST00000393704	O75121 [Direct mapping] Microfibrillar-associated protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	306 aa 34.1 kDa	No	1
MFAP3L-003 ENSP00000377305 ENST00000393702	O75121 [Direct mapping] Microfibrillar-associated protein 3-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	102 aa 11.1 kDa	Yes	0
MFAP3L-004 ENSP00000422571 ENST00000506110	O75121 [Direct mapping] Microfibrillar-associated protein 3-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	102 aa 11.1 kDa	Yes	0
MFAP3L-006 ENSP00000423722 ENST00000502832	D6RCF0 [Direct mapping] Microfibrillar-associated protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	64 aa 7 kDa	No	1
MFAP3L-007 ENSP00000426247 ENST00000506764	D6RGZ8 [Direct mapping] Microfibrillar-associated protein 3-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	90 aa 9.8 kDa	Yes	0
MFAP3L-008 ENSP00000425303 ENST00000504999	D6RDM6 [Direct mapping] Microfibrillar-associated protein 3-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	98 aa 10.7 kDa	Yes	0
MFAP3L-009 ENSP00000423802 ENST00000507601	D6RCC0 [Direct mapping] Microfibrillar-associated protein 3-like Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	44 aa 4.8 kDa	No	0
MFAP3L-010 ENSP00000422791 ENST00000512698	D6RAB5 [Direct mapping] Microfibrillar-associated protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	157 aa 17.8 kDa	No	1
MFAP3L-011 ENSP00000423549 ENST00000510306	D6R9L7 [Direct mapping] Microfibrillar-associated protein 3-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		73 aa 7.7 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.