Cell atlas - SPRR2E - The Human Protein Atlas

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SPRR2E

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SPRR2E
Gene description	Small proline-rich protein 2E
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (hTCEpi)
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SPRR2E
Synonyms
Description	Small proline-rich protein 2E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153093135 - 153106184
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000203785 (version 83.38)
Entrez gene	6704
UniProt	P22531 (UniProt - Evidence at transcript level)
neXtProt	NX_P22531
Antibodypedia	SPRR2E antibodies

PROTEIN BROWSER

SPRR2E-001	SPRR2E-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPRR2E-001 ENSP00000357740 ENST00000368751	P22531 [Direct mapping] Small proline-rich protein 2E Show all	Predicted intracellular proteins Show all	GO:0001533 [cornified envelope] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008544 [epidermis development] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0031424 [keratinization] Show all	72 aa 7.9 kDa	No	0
SPRR2E-002 ENSP00000357739 ENST00000368750	P22531 [Direct mapping] Small proline-rich protein 2E Show all	Predicted intracellular proteins Show all	GO:0001533 [cornified envelope] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008544 [epidermis development] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0031424 [keratinization] Show all	72 aa 7.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.