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SPRR2E

GENERAL INFORMATION

Gene name

 SPRR2E

Gene description

 Small proline-rich protein 2E

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enriched (hTCEpi)
HPA (normal tissue):Group enriched (esophagus, skin, tonsil)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SPRR2E

Synonyms

Description

 Small proline-rich protein 2E (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153093135 - 153106184

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000203785 (version 83.38)

Entrez gene

 6704

UniProt

 P22531 (UniProt - Evidence at transcript level)

neXtProt

 NX_P22531

Antibodypedia

 SPRR2E antibodies

PROTEIN BROWSER
SPRR2E-001
SPRR2E-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPRR2E-001
ENSP00000357740
ENST00000368751
P22531 [Direct mapping]
Small proline-rich protein 2E
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Predicted intracellular proteins
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
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 72 aa
7.9 kDa 		No 0
SPRR2E-002
ENSP00000357739
ENST00000368750
P22531 [Direct mapping]
Small proline-rich protein 2E
Show all
Predicted intracellular proteins
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
Show all
 72 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.