Cell atlas - HSD3B1 - The Human Protein Atlas

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HSD3B1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	HSD3B1
Gene description	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (CACO-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HSD3B1 (HGNC Symbol)
Synonyms	HSD3B, HSDB3, SDR11E1
Description	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119507198 - 119515054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203857 (version 83.38)
Entrez gene	3283
UniProt	P14060 (UniProt - Evidence at protein level)
neXtProt	NX_P14060
Antibodypedia	HSD3B1 antibodies

PROTEIN BROWSER

HSD3B1-001	HSD3B1-004	HSD3B1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD3B1-001 ENSP00000358421 ENST00000369413	P14060 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase Show all	Enzymes ENZYME proteins Oxidoreductases Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0004769 [steroid delta-isomerase activity] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006702 [androgen biosynthetic process] GO:0006703 [estrogen biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006705 [mineralocorticoid biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0030868 [smooth endoplasmic reticulum membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	373 aa 42.3 kDa	No	1
HSD3B1-004 ENSP00000432268 ENST00000528909	P14060 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase Show all	Enzymes ENZYME proteins Oxidoreductases Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0004769 [steroid delta-isomerase activity] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006702 [androgen biosynthetic process] GO:0006703 [estrogen biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006705 [mineralocorticoid biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0030868 [smooth endoplasmic reticulum membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	373 aa 42.3 kDa	No	1
HSD3B1-005 ENSP00000435999 ENST00000531340	E9PRN7 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0006694 [steroid biosynthetic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	82 aa 9.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.