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HSD3B1

GENERAL INFORMATION

Gene name

 HSD3B1

Gene description

 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Cell line enriched (CACO-2)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Paired antibodies with high similarity supports the expression profile.

Reliability score

 Supported based on 3 antibodies.
HPA043261 , HPA043264 , HPA044028
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043261
HPA043264
HPA044028

GENE INFORMATION

Gene name

 HSD3B1 (HGNC Symbol)

Synonyms

 HSD3B, HSDB3, SDR11E1

Description

 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 119507198 - 119515054

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000203857 (version 83.38)

Entrez gene

 3283

UniProt

 P14060 (UniProt - Evidence at protein level)

neXtProt

 NX_P14060

Antibodypedia

 HSD3B1 antibodies

PROTEIN BROWSER
HSD3B1-001
HSD3B1-004
HSD3B1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD3B1-001
ENSP00000358421
ENST00000369413
P14060 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0004769 [steroid delta-isomerase activity]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0006703 [estrogen biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006705 [mineralocorticoid biosynthetic process]
GO:0008202 [steroid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 373 aa
42.3 kDa 		No 1
HSD3B1-004
ENSP00000432268
ENST00000528909
P14060 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0004769 [steroid delta-isomerase activity]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0006703 [estrogen biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006705 [mineralocorticoid biosynthetic process]
GO:0008202 [steroid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 373 aa
42.3 kDa 		No 1
HSD3B1-005
ENSP00000435999
ENST00000531340
E9PRN7 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0006694 [steroid biosynthetic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 82 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.