Cell atlas - HSD3B2 - The Human Protein Atlas

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HSD3B2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	HSD3B2
Gene description	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HSD3B2 (HGNC Symbol)
Synonyms	SDR11E2
Description	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119414931 - 119423035
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203859 (version 83.38)
Entrez gene	3284
UniProt	P26439 (UniProt - Evidence at protein level)
neXtProt	NX_P26439
Antibodypedia	HSD3B2 antibodies

PROTEIN BROWSER

HSD3B2-001	HSD3B2-002	HSD3B2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD3B2-001 ENSP00000358424 ENST00000369416	P26439 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase A0A024R0F9 [Target identity:100%; Query identity:100%] Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0004769 [steroid delta-isomerase activity] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006702 [androgen biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006705 [mineralocorticoid biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0030868 [smooth endoplasmic reticulum membrane] GO:0031966 [mitochondrial membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	372 aa 42.1 kDa	No	1
HSD3B2-002 ENSP00000388292 ENST00000433745	Q5QP01 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0006694 [steroid biosynthetic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	195 aa 21.7 kDa	No	0
HSD3B2-201 ENSP00000445122 ENST00000543831	P26439 [Direct mapping] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase A0A024R0F9 [Target identity:100%; Query identity:100%] Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity] GO:0004769 [steroid delta-isomerase activity] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006694 [steroid biosynthetic process] GO:0006702 [androgen biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006705 [mineralocorticoid biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0030868 [smooth endoplasmic reticulum membrane] GO:0031966 [mitochondrial membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	372 aa 42.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.