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HSD3B2

GENERAL INFORMATION

Gene name

 HSD3B2

Gene description

 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (SK-MEL-30)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Paired antibodies with high similarity supports the expression profile.

Reliability score

 Supported based on 3 antibodies.
HPA043261 , HPA043264 , HPA044028
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043261
HPA043264
HPA044028

GENE INFORMATION

Gene name

 HSD3B2 (HGNC Symbol)

Synonyms

 SDR11E2

Description

 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 119414931 - 119423035

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000203859 (version 83.38)

Entrez gene

 3284

UniProt

 P26439 (UniProt - Evidence at protein level)

neXtProt

 NX_P26439

Antibodypedia

 HSD3B2 antibodies

PROTEIN BROWSER
HSD3B2-001
HSD3B2-002
HSD3B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD3B2-001
ENSP00000358424
ENST00000369416
P26439 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase
A0A024R0F9 [Target identity:100%; Query identity:100%]
Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0004769 [steroid delta-isomerase activity]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006705 [mineralocorticoid biosynthetic process]
GO:0008202 [steroid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0031966 [mitochondrial membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 372 aa
42.1 kDa 		No 1
HSD3B2-002
ENSP00000388292
ENST00000433745
Q5QP01 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0006694 [steroid biosynthetic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
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 195 aa
21.7 kDa 		No 0
HSD3B2-201
ENSP00000445122
ENST00000543831
P26439 [Direct mapping]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 3-beta-hydroxy-Delta(5)-steroid dehydrogenase Steroid Delta-isomerase
A0A024R0F9 [Target identity:100%; Query identity:100%]
Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0003854 [3-beta-hydroxy-delta5-steroid dehydrogenase activity]
GO:0004769 [steroid delta-isomerase activity]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0006704 [glucocorticoid biosynthetic process]
GO:0006705 [mineralocorticoid biosynthetic process]
GO:0008202 [steroid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0031966 [mitochondrial membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 372 aa
42.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.