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DAXX
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DAXX

Gene description

Death-domain associated protein

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression, distinct expression in epididymis, testis and lymphoid tissue.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA008736 , CAB002224 , CAB025546
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

DAXX (HGNC Symbol)

Synonyms

DAP6

Description

Death-domain associated protein (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

33318558 - 33329269

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204209 (version 83.38)

Entrez gene

1616

UniProt

Q9UER7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UER7

Antibodypedia

DAXX antibodies

PROTEIN BROWSER

DAXX-001
DAXX-002
DAXX-005
DAXX-007
DAXX-011
DAXX-201
DAXX-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAXX-001
ENSP00000363668
ENST00000374542
Q9UER7 [Direct mapping]
Death domain-associated protein 6
A0A024RCS3 [Target identity:100%; Query identity:100%]
Death-associated protein 6, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000281 [mitotic cytokinesis]
GO:0000775 [chromosome, centromeric region]
GO:0000792 [heterochromatin]
GO:0001741 [XY body]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002039 [p53 binding]
GO:0003714 [transcription corepressor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005938 [cell cortex]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0008134 [transcription factor binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010038 [response to metal ion]
GO:0010832 [negative regulation of myotube differentiation]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0030578 [PML body organization]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0044297 [cell body]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071454 [cellular response to anoxia]
GO:0097190 [apoptotic signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
740 aa
81.4 kDa
No 0
DAXX-002
ENSP00000266000
ENST00000266000
Q9UER7 [Direct mapping]
Death domain-associated protein 6
A0A024RCS3 [Target identity:100%; Query identity:100%]
Death-associated protein 6, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002039 [p53 binding]
GO:0003714 [transcription corepressor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0008134 [transcription factor binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:1901216 [positive regulation of neuron death]
Show all
740 aa
81.4 kDa
No 0
DAXX-005
ENSP00000408499
ENST00000453407
Q5STR5 [Direct mapping]
Death domain-associated protein 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
130 aa
14.2 kDa
No 0
DAXX-007
ENSP00000406008
ENST00000446403
Q4VX54 [Direct mapping]
Death domain-associated protein 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
178 aa
19.1 kDa
No 0
DAXX-011
ENSP00000390008
ENST00000446511
A2AB94 [Direct mapping]
Death domain-associated protein 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
48 aa
4.8 kDa
No 0
DAXX-201
ENSP00000396876
ENST00000414083
Q9UER7 [Direct mapping]
Death domain-associated protein 6
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002039 [p53 binding]
GO:0003714 [transcription corepressor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0008134 [transcription factor binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:1901216 [positive regulation of neuron death]
Show all
665 aa
73.6 kDa
No 0
DAXX-202
ENSP00000482399
ENST00000620164
Q9UER7 [Direct mapping]
Death domain-associated protein 6
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002039 [p53 binding]
GO:0003714 [transcription corepressor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0008134 [transcription factor binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031072 [heat shock protein binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0050681 [androgen receptor binding]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:1901216 [positive regulation of neuron death]
Show all
688 aa
76.3 kDa
No 0

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