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RXRB

GENERAL INFORMATION

Gene name

 RXRB

Gene description

 Retinoid X receptor, beta

Protein class

 Cancer-related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RH-30)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB002003
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB002003

GENE INFORMATION

Gene name

 RXRB (HGNC Symbol)

Synonyms

 H-2RIIBP, NR2B2, RCoR-1

Description

 Retinoid X receptor, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 33193588 - 33200688

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204231 (version 83.38)

Entrez gene

 6257

UniProt

 P28702 (UniProt - Evidence at protein level)

neXtProt

 NX_P28702

Antibodypedia

 RXRB antibodies

PROTEIN BROWSER
RXRB-001
RXRB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RXRB-001
ENSP00000363812
ENST00000374680
P28702 [Direct mapping]
Retinoic acid receptor RXR-beta
Q5STP9 [Target identity:100%; Query identity:100%]
Retinoid X nuclear receptor beta; Retinoid X receptor, beta
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 533 aa
56.9 kDa 		No 0
RXRB-002
ENSP00000363817
ENST00000374685
P28702 [Direct mapping]
Retinoic acid receptor RXR-beta
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0001893 [maternal placenta development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004886 [9-cis retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0031641 [regulation of myelination]
GO:0042803 [protein homodimerization activity]
GO:0042809 [vitamin D receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046966 [thyroid hormone receptor binding]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060038 [cardiac muscle cell proliferation]
GO:2000273 [positive regulation of receptor activity]
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 537 aa
57.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.