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TAP2

GENERAL INFORMATION

Gene name

 TAP2

Gene description

 Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-251 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA001312
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001312

GENE INFORMATION

Gene name

 TAP2 (HGNC Symbol)

Synonyms

 ABCB3, D6S217E, PSF2, RING11

Description

 Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 32821833 - 32838780

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204267 (version 83.38)

Entrez gene

 6891

UniProt

 Q03519 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03519

Antibodypedia

 TAP2 antibodies

PROTEIN BROWSER
TAP2-001
TAP2-002
TAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAP2-001
ENSP00000364032
ENST00000374897
Q03519 [Direct mapping]
Antigen peptide transporter 2
Q5JNW1 [Target identity:100%; Query identity:100%]
TAP2; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0015197 [peptide transporter activity]
GO:0015433 [peptide antigen-transporting ATPase activity]
GO:0015833 [peptide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0023029 [MHC class Ib protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042825 [TAP complex]
GO:0043657 [host cell]
GO:0046967 [cytosol to ER transport]
GO:0046968 [peptide antigen transport]
GO:0046978 [TAP1 binding]
GO:0046980 [tapasin binding]
GO:0055085 [transmembrane transport]
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 686 aa
75.7 kDa 		No 8
TAP2-002
ENSP00000364034
ENST00000374899
Q03519 [Direct mapping]
Antigen peptide transporter 2
Q9UP03 [Target identity:100%; Query identity:100%]
Transporter 2 isoform; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_a
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0015197 [peptide transporter activity]
GO:0015433 [peptide antigen-transporting ATPase activity]
GO:0015833 [peptide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0019060 [intracellular transport of viral protein in host cell]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0023029 [MHC class Ib protein binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042825 [TAP complex]
GO:0043657 [host cell]
GO:0046967 [cytosol to ER transport]
GO:0046968 [peptide antigen transport]
GO:0046978 [TAP1 binding]
GO:0046980 [tapasin binding]
GO:0055085 [transmembrane transport]
Show all
 653 aa
72 kDa 		No 8
TAP2-201
ENSP00000481712
ENST00000620123
A0A087WYD6 [Direct mapping]
Antigen peptide transporter 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent]
GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I]
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0015197 [peptide transporter activity]
GO:0015440 [peptide-transporting ATPase activity]
GO:0015833 [peptide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042287 [MHC protein binding]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0042825 [TAP complex]
GO:0055085 [transmembrane transport]
Show all
 702 aa
77.6 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.