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Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Q03519 [Direct mapping] Antigen peptide transporter 2 Q5JNW1 [Target identity:100%; Query identity:100%] TAP2; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA
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Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0043657 [host cell] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0043657 [host cell] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015197 [peptide transporter activity] GO:0015440 [peptide-transporting ATPase activity] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042287 [MHC protein binding] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0055085 [transmembrane transport]
