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RNA tissue category: Group enriched (breast, vagina)
GENE INFORMATION
Gene name
HSPA1A (HGNC Symbol)
Synonyms
HSP70-1, HSPA1
Description
Heat shock 70kDa protein 1A (HGNC Symbol)
Entrez gene summary
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
P0DMV8 [Direct mapping] Heat shock 70 kDa protein 1A A8K5I0 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 103; Heat shock 70kDa protein 1A; Heat shock 70kDa protein 1B; cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA
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Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers
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GO:0000151 [ubiquitin ligase complex] GO:0001618 [virus receptor activity] GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016234 [inclusion body] GO:0016887 [ATPase activity] GO:0019899 [enzyme binding] GO:0031072 [heat shock protein binding] GO:0031397 [negative regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032757 [positive regulation of interleukin-8 production] GO:0034599 [cellular response to oxidative stress] GO:0034605 [cellular response to heat] GO:0042026 [protein refolding] GO:0042623 [ATPase activity, coupled] GO:0043488 [regulation of mRNA stability] GO:0044183 [protein binding involved in protein folding] GO:0046034 [ATP metabolic process] GO:0046718 [viral entry into host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0055131 [C3HC4-type RING finger domain binding] GO:0060548 [negative regulation of cell death] GO:0070370 [cellular heat acclimation] GO:0070434 [positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0072562 [blood microparticle] GO:0090084 [negative regulation of inclusion body assembly] GO:1900034 [regulation of cellular response to heat] GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902380 [positive regulation of endoribonuclease activity] GO:1903265 [positive regulation of tumor necrosis factor-mediated signaling pathway] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
