Expression of CSHL1 in cancer - Summary - The Human Protein Atlas

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CSHL1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CSHL1
Gene description	Chorionic somatomammotropin hormone-like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA043715 , CAB025646
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043715	CAB025646

GENE INFORMATION
Gene name	CSHL1 (HGNC Symbol)
Synonyms	CS-5, CSHP1, CSL, hCS-L, MGC149868
Description	Chorionic somatomammotropin hormone-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63909597 - 63918838
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204414 (version 83.38)
Entrez gene	1444
UniProt	Q14406 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14406
Antibodypedia	CSHL1 antibodies

PROTEIN BROWSER

CSHL1-001	CSHL1-002	CSHL1-003	CSHL1-006	CSHL1-008	CSHL1-009	CSHL1-201	CSHL1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSHL1-001 ENSP00000316360 ENST00000346606	Q14406 [Direct mapping] Chorionic somatomammotropin hormone-like 1 I6L999 [Target identity:100%; Query identity:100%] Chorionic somatomammotropin hormone-like 1; HCG1749481, isoform CRA_ab Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0046872 [metal ion binding] Show all	128 aa 14.9 kDa	No	0
CSHL1-002 ENSP00000259003 ENST00000259003	A0A0B4J1R0 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	160 aa 18.2 kDa	Yes	0
CSHL1-003 ENSP00000452900 ENST00000561003	H0YKQ4 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	178 aa 19.6 kDa	No	0
CSHL1-006 ENSP00000413501 ENST00000450719	H7C3R7 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	167 aa 18.6 kDa	No	0
CSHL1-008 ENSP00000402632 ENST00000438387	Q14406 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0046872 [metal ion binding] Show all	139 aa 15.9 kDa	No	0
CSHL1-009 ENSP00000309524 ENST00000309894	Q14406 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0046872 [metal ion binding] Show all	222 aa 25.4 kDa	Yes	0
CSHL1-201 ENSP00000376569 ENST00000392824	J3QT06 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	217 aa 24.9 kDa	Yes	0
CSHL1-202 ENSP00000483369 ENST00000611417	A0A087X0G4 [Direct mapping] Chorionic somatomammotropin hormone-like 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	217 aa 24.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.