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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABCF1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCF1

Gene description

ATP-binding cassette, sub-family F (GCN20), member 1

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA017578
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017578

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic staining was observed in most malignancies. A majority of prostate cancers and several cholangiocarcinomas, cervical, endometrial, liver and lung cancers were strongly stained.

GENE INFORMATION

Gene name

ABCF1 (HGNC Symbol)

Synonyms

ABC50, EST123147

Description

ATP-binding cassette, sub-family F (GCN20), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

30571376 - 30597179

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204574 (version 83.38)

Entrez gene

23

UniProt

Q8NE71 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NE71

Antibodypedia

ABCF1 antibodies

PROTEIN BROWSER

ABCF1-001
ABCF1-002
ABCF1-003
ABCF1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCF1-001
ENSP00000313603
ENST00000326195
Q8NE71 [Direct mapping]
ATP-binding cassette sub-family F member 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006954 [inflammatory response]
GO:0008135 [translation factor activity, RNA binding]
GO:0008494 [translation activator activity]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0042788 [polysomal ribosome]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0055085 [transmembrane transport]
Show all
845 aa
95.9 kDa
No 0
ABCF1-002
ENSP00000365728
ENST00000376545
Q8NE71 [Direct mapping]
ATP-binding cassette sub-family F member 1
Q2L6I2 [Target identity:100%; Query identity:100%]
ABC50 protein; ATP-binding cassette, sub-family F (GCN20), member 1; ATP-binding cassette, sub-family F (GCN20), member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006954 [inflammatory response]
GO:0008135 [translation factor activity, RNA binding]
GO:0008494 [translation activator activity]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0042788 [polysomal ribosome]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0055085 [transmembrane transport]
Show all
807 aa
91.7 kDa
No 0
ABCF1-003
ENSP00000405512
ENST00000441867
Q5STZ8 [Direct mapping]
ATP-binding cassette sub-family F member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
340 aa
38.4 kDa
No 0
ABCF1-006
ENSP00000440893
ENST00000468958
F5GYK6 [Direct mapping]
ATP-binding cassette sub-family F member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
105 aa
11.7 kDa
No 0

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