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ABCF1

GENERAL INFORMATION

Gene name

 ABCF1

Gene description

 ATP-binding cassette, sub-family F (GCN20), member 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017578
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ABCF1 (HGNC Symbol)

Synonyms

 ABC50, EST123147

Description

 ATP-binding cassette, sub-family F (GCN20), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30571376 - 30597179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204574 (version 83.38)

Entrez gene

 23

UniProt

 Q8NE71 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NE71

Antibodypedia

 ABCF1 antibodies

PROTEIN BROWSER
ABCF1-001
ABCF1-002
ABCF1-003
ABCF1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCF1-001
ENSP00000313603
ENST00000326195
Q8NE71 [Direct mapping]
ATP-binding cassette sub-family F member 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006954 [inflammatory response]
GO:0008135 [translation factor activity, RNA binding]
GO:0008494 [translation activator activity]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0042788 [polysomal ribosome]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0055085 [transmembrane transport]
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 845 aa
95.9 kDa 		No 0
ABCF1-002
ENSP00000365728
ENST00000376545
Q8NE71 [Direct mapping]
ATP-binding cassette sub-family F member 1
Q2L6I2 [Target identity:100%; Query identity:100%]
ABC50 protein; ATP-binding cassette, sub-family F (GCN20), member 1; ATP-binding cassette, sub-family F (GCN20), member 1, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006954 [inflammatory response]
GO:0008135 [translation factor activity, RNA binding]
GO:0008494 [translation activator activity]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0042788 [polysomal ribosome]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0055085 [transmembrane transport]
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 807 aa
91.7 kDa 		No 0
ABCF1-003
ENSP00000405512
ENST00000441867
Q5STZ8 [Direct mapping]
ATP-binding cassette sub-family F member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
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 340 aa
38.4 kDa 		No 0
ABCF1-006
ENSP00000440893
ENST00000468958
F5GYK6 [Direct mapping]
ATP-binding cassette sub-family F member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
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 105 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.