Cell atlas - DDR1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DDR1
Gene description	Discoidin domain receptor tyrosine kinase 1
Protein class	CD markers Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	43
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions & nucleoplasm.
RNA cell category	Cell line enhanced (T-47d, HaCaT, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cell Junctions (approved)
Mouse	Localized to the Nucleoplasm, Cell Junctions in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057194
	SHOW MORE

ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, HaCaT, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions & nucleoplasm.

Main location

Nucleoplasm (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA057194	A-431	Nucleoplasm
HPA057194	A-431	Cell Junctions
HPA057194	MCF7	Nucleoplasm
HPA057194	MCF7	Cell Junctions
HPA057194	U-2 OS	Nucleoplasm
HPA057194	U-2 OS	Cell Junctions

MOUSE CELLS

Main location

Nucleoplasm, Cell Junctions

Mouse gene

ENSMUSG00000003534 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA057194	NIH 3T3	Nucleoplasm
	HPA057194	NIH 3T3	Cell Junctions

GENE INFORMATION
Gene name	DDR1 (HGNC Symbol)
Synonyms	CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6
Description	Discoidin domain receptor tyrosine kinase 1 (HGNC Symbol)
Entrez gene summary	Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	30876421 - 30900156
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204580 (version 83.38)
Entrez gene	780
UniProt	Q08345 (UniProt - Evidence at protein level)
neXtProt	NX_Q08345
Antibodypedia	DDR1 antibodies

PROTEIN BROWSER

DDR1-001	DDR1-002	DDR1-003	DDR1-005	DDR1-006	DDR1-007	DDR1-009	DDR1-010	DDR1-012	DDR1-013	DDR1-014	DDR1-015	DDR1-016	DDR1-018	DDR1-020	DDR1-022	DDR1-023	DDR1-024	DDR1-025	DDR1-026	DDR1-027	DDR1-028	DDR1-030	DDR1-031	DDR1-032	DDR1-034	DDR1-035	DDR1-036	DDR1-037	DDR1-038	DDR1-039	DDR1-040	DDR1-041	DDR1-044	DDR1-047	DDR1-048	DDR1-049	DDR1-050	DDR1-051	DDR1-205	DDR1-206	DDR1-207	DDR1-208

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDR1-001 ENSP00000406091 ENST00000454612	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCQ1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	876 aa 97.2 kDa	Yes	2
DDR1-002 ENSP00000365752 ENST00000376568	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCL1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	913 aa 101.1 kDa	Yes	2
DDR1-003 ENSP00000365753 ENST00000376569	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCQ1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	876 aa 97.2 kDa	Yes	2
DDR1-005 ENSP00000318217 ENST00000324771	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCL1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	913 aa 101.1 kDa	Yes	2
DDR1-006 ENSP00000365751 ENST00000376567	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCQ1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	876 aa 97.2 kDa	Yes	2
DDR1-007 ENSP00000398682 ENST00000417521	A2ABM8 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] Show all	493 aa 53.8 kDa	No	1
DDR1-009 ENSP00000424003 ENST00000484556	H0Y9F4 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] Show all	277 aa 30.8 kDa	No	0
DDR1-010 ENSP00000426420 ENST00000460944	E7EPH4 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		286 aa 31.9 kDa	Yes	0
DDR1-012 ENSP00000407699 ENST00000418800	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCQ1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	876 aa 97.2 kDa	Yes	2
DDR1-013 ENSP00000379631 ENST00000396342	A2ABL0 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.2 kDa	Yes	0
DDR1-014 ENSP00000390593 ENST00000428153	E7EQ30 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		267 aa 29.6 kDa	Yes	0
DDR1-015 ENSP00000422974 ENST00000503670	D6R9C4 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.4 kDa	Yes	0
DDR1-016 ENSP00000409682 ENST00000421124	A2ABL2 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.2 kDa	Yes	0
DDR1-018 ENSP00000427552 ENST00000513240	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCJ0 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001952 [regulation of cell-matrix adhesion] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0008285 [negative regulation of cell proliferation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030198 [extracellular matrix organization] GO:0031100 [organ regeneration] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0043583 [ear development] GO:0043588 [skin development] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060749 [mammary gland alveolus development] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	919 aa 101.8 kDa	Yes	1
DDR1-020 ENSP00000422442 ENST00000508312	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	894 aa 99.1 kDa	Yes	2
DDR1-022 ENSP00000421189 ENST00000505066	E7EVW6 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.5 kDa	Yes	0
DDR1-023 ENSP00000424346 ENST00000502955	D6RB82 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.8 kDa	Yes	0
DDR1-024 ENSP00000420833 ENST00000505534	E7EN94 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 10.8 kDa	Yes	0
DDR1-025 ENSP00000424468 ENST00000503180	D6RB35 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.4 kDa	Yes	0
DDR1-026 ENSP00000423906 ENST00000504679	E7ETX3 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.2 kDa	Yes	0
DDR1-027 ENSP00000423749 ENST00000503495	E7EUP7 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 21.5 kDa	Yes	0
DDR1-028 ENSP00000427369 ENST00000508317	E7EUD5 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.8 kDa	Yes	0
DDR1-030 ENSP00000422331 ENST00000509639	E7ES06 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.2 kDa	Yes	0
DDR1-031 ENSP00000392413 ENST00000412274	D6RBU7 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.1 kDa	Yes	0
DDR1-032 ENSP00000424703 ENST00000507901	E7EXB0 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.1 kDa	Yes	0
DDR1-034 ENSP00000425713 ENST00000507046	E7EQ23 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.4 kDa	Yes	0
DDR1-035 ENSP00000425113 ENST00000511510	E7ESR9 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 15.8 kDa	Yes	0
DDR1-036 ENSP00000394273 ENST00000437124	E7ERI6 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.9 kDa	Yes	0
DDR1-037 ENSP00000424758 ENST00000504651	E7EX99 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.7 kDa	Yes	0
DDR1-038 ENSP00000423928 ENST00000513043	D6RB35 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.4 kDa	Yes	0
DDR1-039 ENSP00000426229 ENST00000512694	E7EPN2 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.8 kDa	Yes	0
DDR1-040 ENSP00000422467 ENST00000515233	E7ERN0 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.3 kDa	Yes	0
DDR1-041 ENSP00000423492 ENST00000515881	E7ENJ2 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9 kDa	Yes	0
DDR1-044 ENSP00000421152 ENST00000515219	D6RGW5 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.8 kDa	No	0
DDR1-047 ENSP00000427597 ENST00000504927	E7ETI3 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.6 kDa	Yes	0
DDR1-048 ENSP00000421719 ENST00000512336	E7EVT1 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 11.9 kDa	Yes	0
DDR1-049 ENSP00000422108 ENST00000512725	E7ERN0 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.3 kDa	Yes	0
DDR1-050 ENSP00000409400 ENST00000424544	H0Y717 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 21.8 kDa	Yes	0
DDR1-051 ENSP00000427124 ENST00000514434	H0YAH6 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] Show all	172 aa 18.5 kDa	No	0
DDR1-205 ENSP00000365754 ENST00000376570	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCQ1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_d Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	876 aa 97.2 kDa	Yes	2
DDR1-206 ENSP00000365759 ENST00000376575	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	243 aa 27.1 kDa	Yes	0
DDR1-207 ENSP00000405998 ENST00000446312	A0A0A0MSX3 [Direct mapping] Epithelial discoidin domain-containing receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	767 aa 85.5 kDa	Yes	1
DDR1-208 ENSP00000405039 ENST00000452441	Q08345 [Direct mapping] Epithelial discoidin domain-containing receptor 1 A0A024RCL1 [Target identity:100%; Query identity:100%] Discoidin domain receptor family, member 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0010715 [regulation of extracellular matrix disassembly] GO:0014909 [smooth muscle cell migration] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0038062 [protein tyrosine kinase collagen receptor activity] GO:0038063 [collagen-activated tyrosine kinase receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0043235 [receptor complex] GO:0044319 [wound healing, spreading of cells] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0061302 [smooth muscle cell-matrix adhesion] GO:0070062 [extracellular exosome] Show all	913 aa 101.1 kDa	Yes	2