Expression of MALRD1 in cancer - Summary - The Human Protein Atlas

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MALRD1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MALRD1
Gene description	MAM and LDL receptor class A domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Cell line enriched (Karpas-707)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046848
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046848

GENE INFORMATION
Gene name	MALRD1 (HGNC Symbol)
Synonyms	bA265G8.2, C10orf112, Diet1
Description	MAM and LDL receptor class A domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p12.31
Chromosome location (bp)	19048771 - 19790401
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204740 (version 83.38)
Entrez gene	340895
UniProt	Q5VYJ5 (UniProt - Inferred from homology)
neXtProt	NX_Q5VYJ5
Antibodypedia	MALRD1 antibodies

PROTEIN BROWSER

MALRD1-001	MALRD1-002	MALRD1-004	MALRD1-005	MALRD1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MALRD1-001 ENSP00000366477 ENST00000377266	U5GXS0 [Direct mapping] MAM and LDL-receptor class A domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1486 aa 165.4 kDa	No	1
MALRD1-002 ENSP00000366476 ENST00000377265	H0Y3D6 [Direct mapping] MAM and LDL-receptor class A domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	507 aa 55.1 kDa	No	1
MALRD1-004 ENSP00000404330 ENST00000441070	B7ZBR1 [Direct mapping] MAM and LDL-receptor class A domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] Show all	258 aa 28.8 kDa	No	0
MALRD1-005 ENSP00000403218 ENST00000418367	B7ZBP3 [Direct mapping] MAM and LDL-receptor class A domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.7 kDa	No	0
MALRD1-201 ENSP00000412763 ENST00000454679	Q5VYJ5 [Direct mapping] MAM and LDL-receptor class A domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042632 [cholesterol homeostasis] GO:0070858 [negative regulation of bile acid biosynthetic process] Show all	2156 aa 241 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.