Expression of PNMAL2 in cancer - Summary

GENERAL INFORMATION
Gene name	PNMAL2
Gene description	Paraneoplastic Ma antigen family-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, AN3-CA, SH-SY5Y)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in a group of tissues, including CNS and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA054810
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA054810

GENE INFORMATION
Gene name	PNMAL2 (HGNC Symbol)
Synonyms	KIAA1183
Description	Paraneoplastic Ma antigen family-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46486906 - 46496498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204851 (version 83.38)
Entrez gene	57469
UniProt	Q9ULN7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9ULN7
Antibodypedia	PNMAL2 antibodies

PROTEIN BROWSER

PNMAL2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMAL2-001 ENSP00000473036 ENST00000599531	Q9ULN7 [Direct mapping] PNMA-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		635 aa 68.6 kDa	No	0