Expression of GRXCR2 in cancer - Summary - The Human Protein Atlas

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GRXCR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRXCR2
Gene description	Glutaredoxin, cysteine rich 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. No internal RNA expression data available for correlation.
Reliability score	Uncertain based on 1 antibody. HPA059421
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059421

GENE INFORMATION
Gene name	GRXCR2 (HGNC Symbol)
Synonyms	DFNB101
Description	Glutaredoxin, cysteine rich 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. [provided by RefSeq, Jun 2014]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	145859733 - 145872968
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204928 (version 83.38)
Entrez gene	643226
UniProt	A6NFK2 (UniProt - Inferred from homology)
neXtProt	NX_A6NFK2
Antibodypedia	GRXCR2 antibodies

PROTEIN BROWSER

GRXCR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRXCR2-001 ENSP00000367214 ENST00000377976	A6NFK2 [Direct mapping] Glutaredoxin domain-containing cysteine-rich protein 2 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005902 [microvillus] GO:0007605 [sensory perception of sound] GO:0031072 [heat shock protein binding] GO:0032420 [stereocilium] GO:0051082 [unfolded protein binding] Show all	248 aa 28.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.