Expression of PSG5 in cancer - Summary - The Human Protein Atlas

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PSG5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG5
Gene description	Pregnancy specific beta-1-glycoprotein 5
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+, HBF TERT88)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG5 (HGNC Symbol)
Synonyms	FL-NCA-3, PSG
Description	Pregnancy specific beta-1-glycoprotein 5 (HGNC Symbol)
Entrez gene summary	The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43166256 - 43186536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204941 (version 83.38)
Entrez gene	5673
UniProt	Q15238 (UniProt - Evidence at protein level)
neXtProt	NX_Q15238
Antibodypedia	PSG5 antibodies

PROTEIN BROWSER

PSG5-001	PSG5-002	PSG5-003	PSG5-004	PSG5-005	PSG5-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG5-001 ENSP00000382334 ENST00000366175	Q15238 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 A0A024R0S1 [Target identity:100%; Query identity:100%] Pregnancy specific beta-1-glycoprotein 5, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	335 aa 37.7 kDa	Yes	0
PSG5-002 ENSP00000386008 ENST00000407356	Q15238 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 A0A024R0S1 [Target identity:100%; Query identity:100%] Pregnancy specific beta-1-glycoprotein 5, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	335 aa 37.7 kDa	Yes	0
PSG5-003 ENSP00000344413 ENST00000342951	Q15238 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 A0A024R0S1 [Target identity:100%; Query identity:100%] Pregnancy specific beta-1-glycoprotein 5, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	335 aa 37.7 kDa	Yes	0
PSG5-004 ENSP00000385250 ENST00000404580	E7EQY3 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	333 aa 37.6 kDa	Yes	0
PSG5-005 ENSP00000386053 ENST00000407568	E9PC55 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17.5 kDa	Yes	0
PSG5-010 ENSP00000471866 ENST00000599812	M0R1G9 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	428 aa 48 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.