Expression of HTN3 in cancer - Summary - The Human Protein Atlas

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HTN3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HTN3
Gene description	Histatin 3
Protein class	Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in salivary gland

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB073541
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB073541

GENE INFORMATION
Gene name	HTN3 (HGNC Symbol)
Synonyms	HIS2
Description	Histatin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	70028413 - 70036538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205649 (version 83.38)
Entrez gene	3347
UniProt	P15516 (UniProt - Evidence at protein level)
neXtProt	NX_P15516
Antibodypedia	HTN3 antibodies

PROTEIN BROWSER

HTN3-001	HTN3-006	HTN3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTN3-001 ENSP00000437158 ENST00000526767	P15516 [Direct mapping] Histatin-3 Histatin-3 His3-(20-44)-peptide His3-(20-43)-peptide His3-(20-32)-peptide His3-(20-31)-peptide His3-(20-30)-peptide His3-(24-32)-peptide His3-(24-31)-peptide His3-(24-30)-peptide His3-(25-32)-peptide His3-(25-30)-peptide His3-(26-32)-peptide His3-(26-31)-peptide His3-(26-30)-peptide His3-(31-51)-peptide His3-(31-44)-peptide His3-(31-43)-peptide His3-(32-44)-peptide His3-(32-43)-peptide His3-(33-44)-peptide His3-(33-43)-peptide His3-(34-44)-peptide His3-(34-43)-peptide His3-(45-51)-peptide His3-(47-51)-peptide His3-(48-51)-peptide Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0031214 [biomineral tissue development] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] Show all	51 aa 6.1 kDa	Yes	0
HTN3-006 ENSP00000432561 ENST00000530128	P15516 [Direct mapping] Histatin-3 Histatin-3 His3-(20-44)-peptide His3-(20-43)-peptide His3-(20-32)-peptide His3-(20-31)-peptide His3-(20-30)-peptide His3-(24-32)-peptide His3-(24-31)-peptide His3-(24-30)-peptide His3-(25-32)-peptide His3-(25-30)-peptide His3-(26-32)-peptide His3-(26-31)-peptide His3-(26-30)-peptide His3-(31-51)-peptide His3-(31-44)-peptide His3-(31-43)-peptide His3-(32-44)-peptide His3-(32-43)-peptide His3-(33-44)-peptide His3-(33-43)-peptide His3-(34-44)-peptide His3-(34-43)-peptide His3-(45-51)-peptide His3-(47-51)-peptide His3-(48-51)-peptide Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0031214 [biomineral tissue development] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] Show all	51 aa 6.1 kDa	Yes	0
HTN3-010 ENSP00000370445 ENST00000381057	X6RAH8 [Direct mapping] Histatin-3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0042742 [defense response to bacterium] Show all	41 aa 4.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.